1,030 research outputs found
Encoding Financial Records for Historical Research
The standard guidelines for scholarly markup of digitized sources, those of the Text Encoding Initiative (TEI), do not provide adequate models for representing the semantic value of financial records. Nevertheless, various digitization projects have used TEI-compliant XML to encode manuscript collections that include financial documentation. And now a handful of projects have begun to use TEI as they turn attention to financial records per se, revealing a need for extended markup guidelines to increase the accessibility of these resources. We will organize a meeting of historians, archivists, and technologists as a first step toward developing standards for markup of transcribed text and the application of metadata that will allow for searching across collections of manuscript financial records. Ultimately, the process begun with this meeting will lead to an extension of current TEI guidelines to include a module on financial records
Probability of Causation for Lung Cancer After Exposure to Radon Progeny: A Comparison of Models and Data
The estimates of lung cancer risk due to the exposure to radon decay products are based on different data sets from underground mining and on different mathematical models that are used to fit the data. Diagrams of the excess relative rate per 100 working level months in its dependence on age at exposure and age attained are shown to be a useful tool to elucidate the influence that is due to the choice of the model, and to assess the differences between the data from the major western cohorts and those from the Czech uranium miners. It is seen that the influence of the choice of the model is minor compared to the difference between the data sets. The results are used to derive attributable lifetime risks and probabilities of causation for lung cancer following radon progeny exposures
A Survey of the Czechoslovak Follow-up of Lung Cancer Mortality in Uranium Miners
The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny. An analysis of the dose dependence of lung cancer mortality is performed by nonparametric and, subsequently, by parametric methods. In the first step, two-dimensional isotonic regression is employed to derive the lung cancer mortality rate and the relative excess risk as functions of age attained and of lagged cumulated exposure. In a second step, analytical fits in terms of relative risk models are derived. The treatment is largely analogous to the methods applied by the BEIR IV Committee to other major cohorts of uranium miners. There is a marked dependence of the excess risk on age attained and on time since exposure. A specific characteristic of the Czechoslovak data is the nonlinearity of the dependence of the lung cancer excess risk on the cumulated exposure; exposures on the order of 100 working level months or less appear to be more effective per working level month than larger exposures but, in the absence of an internal control group, this cannot be excluded to be due to confounders such as smoking or environmental exposures. A further notable observation is the association of larger excess risks with longer protraction of the exposures
Studies of resistance switching effects in metal/YBa2Cu3O7-x interface junctions
Current-voltage characteristics of planar junctions formed by an epitaxial
c-axis oriented YBa2Cu3O7-x thin film micro-bridge and Ag counter-electrode
were measured in the temperature range from 4.2 K to 300 K. A hysteretic
behavior related to switching of the junction resistance from a high-resistive
to a low-resistive state and vice-versa was observed and analyzed in terms of
the maximal current bias and temperature dependence. The same effects were
observed on a sub-micrometer scale YBa2Cu3O7-x thin film - PtIr point contact
junctions using Scanning Tunneling Microscope. These phenomena are discussed
within a diffusion model, describing an oxygen vacancy drift in YBa2Cu3O7-x
films in the nano-scale vicinity of the junction interface under applied
electrical fields.Comment: To be published in Applied Surface Science
Effect of crystallographic anisotropy on the resistance switching phenomenon in perovskites
Resistance switching effects in metal/perovskite contacts based on epitaxial
c-axis oriented Y-Ba-Cu-O (YBCO) thin films with different crystallographic
orientations have been studied. Three types of Ag/YBCO junctions with the
contact restricted to (i) c-axis direction, (ii) ab-plane direction, and (iii)
both were designed and fabricated, and their current-voltage characteristics
have been measured. The type (i) junctions exhibited conventional bipolar
resistance switching behavior, whereas in other two types the low-resistance
state was unsteady and their resistance quickly relaxed to the initial
high-resistance state. Physical mechanism based on the oxygen diffusion
scenario, explaining such behavior, is discussed.Comment: The final version was published in Journal of Applied Physics (2012
Radon and risk of extrapulmonary cancers: results of the German uranium miners' cohort study, 1960–2003
Data from the German miners' cohort study were analysed to investigate whether radon in ambient air causes cancers other than lung cancer. The cohort includes 58 987 men who were employed for at least 6 months from 1946 to 1989 at the former Wismut uranium mining company in Eastern Germany. A total of 20 684 deaths were observed in the follow-up period from 1960 to 2003. The death rates for 24 individual cancer sites were compared with the age and calendar year-specific national death rates. Internal Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to radon in working level months (WLM). The number of deaths observed (O) for extrapulmonary cancers combined was close to that expected (E) from national rates (n=3340, O/E=1.02; 95% confidence interval (CI): 0.98–1.05). Statistically significant increases in mortality were recorded for cancers of the stomach (O/E=1.15; 95% CI: 1.06–1.25) and liver (O/E=1.26; 95% CI: 1.07–1.48), whereas significant decreases were found for cancers of the tongue, mouth, salivary gland and pharynx combined (O/E=0.80; 95% CI: 0.65–0.97) and those of the bladder (O/E=0.82; 95% CI: 0.70–0.95). A statistically significant relationship with cumulative radon exposure was observed for all extrapulmonary cancers (ERR/WLM=0.014%; 95% CI: 0.006–0.023%). Most sites showed positive exposure–response relationships, but these were insignificant or became insignificant after adjustment for potential confounders such as arsenic or dust exposure. The present data provide some evidence of increased risk of extrapulmonary cancers associated with radon, but chance and confounding cannot be ruled out
Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis
The attachment of a sugar to a hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. The enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate mannose synthase (DPMS), which generates the mannose donor for glycosylation in the endoplasmic reticulum. Here we report the 3.0Å resolution crystal structure of GtrB, a glucose-specific PI-GT from Synechocystis, showing a tetramer in which each protomer contributes two helices to a membrane-spanning bundle. The active site is 15 Å from the membrane, raising the question of how water-soluble and membrane-embedded substrates are brought into apposition for catalysis. A conserved juxtamembrane domain harbours disease mutations, which compromised activity in GtrB in vitro and in humanDPM1 tested in zebrafish. We hypothesize a role of this domain in shielding the polyisoprenyl-phosphate for transport to the active site. Our results reveal the basis of PI-GT function, and provide a potential molecular explanation for DPM1-related disease
Shower development of particles with momenta from 15 GeV to 150 GeV in the CALICE scintillator-tungsten hadronic calorimeter
We present a study of showers initiated by electrons, pions, kaons, and
protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE
scintillator-tungsten analogue hadronic calorimeter. The data were recorded at
the CERN Super Proton Synchrotron in 2011. The analysis includes measurements
of the calorimeter response to each particle type as well as measurements of
the energy resolution and studies of the longitudinal and radial shower
development for selected particles. The results are compared to Geant4
simulations (version 9.6.p02). In the study of the energy resolution we include
previously published data with beam momenta from 1 GeV to 10 GeV recorded at
the CERN Proton Synchrotron in 2010.Comment: 35 pages, 21 figures, 8 table
Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter
The spatial development of hadronic showers in the CALICE scintillator-steel
analogue hadron calorimeter is studied using test beam data collected at CERN
and FNAL for single positive pions and protons with initial momenta in the
range from 10 to 80 GeV/c. Both longitudinal and radial development of hadron
showers are parametrised with two-component functions. The parametrisation is
fit to test beam data and simulations using the QGSP_BERT and FTFP_BERT physics
lists from Geant4 version 9.6. The parameters extracted from data and simulated
samples are compared for the two types of hadrons. The response to pions and
the ratio of the non-electromagnetic to the electromagnetic calorimeter
response, h/e, are estimated using the extrapolation and decomposition of the
longitudinal profiles.Comment: 38 pages, 19 figures, 5 tables; author list changed; submitted to
JINS
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